
Anesthesiology as a whole has a healthy number of scientific debates a-raging: BIS or no BIS, Nerve stim vs Ultrasound, Swan vs TEE.
One debate in particular regarding the maintainence of MAP during c-sections was recently highlighted in this months Anesthesiology. CW in years past has held that uterine perfusion was best maintained with ephedrine vs phenylephrine. This was recently callled into question when Lee et. al showed no change in fetal ph after either pressor was given.
This months article by N.Kee et. al. seems to find improved outcomes with phenyleprine:
Ephedrine crosses the placenta to a greater extent and undergoes less early metabolism and/or redistribution in the fetus compared with phenylephrine. The associated increased fetal concentrations of lactate, glucose, and catecholamines support the hypothesis that depression of fetal pH and base excess with ephedrine is related to metabolic effects secondary to stimulation of fetal β-adrenergic receptors. Despite historical evidence suggesting uteroplacental blood flow may be better maintained with ephedrine, the overall effect of the vasopressors on fetal oxygen supply and demand balance may favor phenylephrine
Interesting.




